European Urology SupplementsBob Djavana, et al. - In humans, androgens balance cell proliferation and apoptosis, ensuring normal growth and development of the prostate, but also driving pathologic gland enlargement in benign prostatic hyperplasia (BPH) and prostate cancer. The two main androgens are testosterone and dihydrotestosterone (DHT). Reducing testosterone levels results in significant sexual side-effects, whereas reducing DHT does not result in any major safety or tolerability issues…Dutasteride demonstrates sustained improvement in symptom score and maximal flow rate with no increase in prostate volume up to 4 yr

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